Scientists from Shanghai Jiao Tong University conducted a study that found two chemical compounds from the group of "forever chemicals" — perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA) — capable of accelerating biological aging processes in middle-aged men. This information was published in the journal Frontiers in Aging, referencing the source Lenta.ru.
PFAS (per- and polyfluoroalkyl substances) are called "forever chemicals" due to their persistence. These synthetic materials are widely used in the production of non-stick coatings, water-repellent fabrics, packaging, and firefighting foam. Due to their strong chemical bonds, PFAS do not break down in the ecosystem and accumulate in water, soil, and the human body. It has previously been established that some of these substances may increase the risk of cancer, obesity, infertility, and hormonal disorders.
During the analysis, researchers examined data from 326 participants in the National Health and Nutrition Examination Survey in the United States conducted in 1999-2000. The scientists measured the levels of 11 PFAS in blood samples from the subjects and assessed DNA methylation — changes that affect gene activity. To calculate the biological age of the participants, 12 models of "epigenetic clocks" were used, after which the results were compared with chronological age.
PFNA and PFOSA were found in the blood of 95% of the study participants. Moreover, higher concentrations of these substances were statistically significantly associated with accelerated epigenetic aging in men aged 50 to 64, while a similar association was not established in women.
The authors of the study suggest that middle-aged men may be particularly susceptible to the influence of external stressors, making them more vulnerable. Additionally, lifestyle and accompanying factors, such as smoking, may influence the aging process, potentially exacerbating the effects of chemicals.
Previously, representatives of the FMBA reported that the aging process in humans begins at the age of 25.
