The thymus gland functions actively during the first three years of life, after which, by the time of puberty, its activity begins to slow down. By the age of 40, the thymus virtually loses its functionality, depleting its reserves. These reserves are used up quickly, making the elderly organism more vulnerable to infections and other threats.
To address this issue, researchers sought an alternative source for the production of T-lymphocytes and turned their attention to the liver.
In experiments with mice, scientists identified three proteins responsible for the synthesis of T-cells, which gradually lose their functions over time. Using mRNA therapy, these proteins were introduced into the livers of older rodents, which facilitated the activation of T-cell production.
The results were promising: the test animals showed an increase in both the quantity and diversity of T-lymphocytes. An improved response to vaccination was also observed, enhancing the immune defense against cancer formations. Thus, the scientists were able to rejuvenate the immune system and activate its function.
